MASTL INHIBITION PROMOTES MITOTIC CATASTROPHE THROUGH PP2A ACTIVATION TO INHIBIT CANCER GROWTH AND RADIORESISTANCE IN BREAST CANCER CELLS

MASTL inhibition promotes mitotic catastrophe through PP2A activation to inhibit cancer growth and radioresistance in breast cancer cells

Abstract Background Although MASTL (microtubule-associated serine/threonine kinase-like) is a key mitotic kinase that regulates mitotic progression through the inactivation of tumor suppressor protein phosphatase 2A (PP2A), the antitumor mechanism of MASTL targeting in cancer cells is still unclear.Methods MASTL expression was evaluated by using br

read more



Further characterization of the effect of the prototypical antidepressant imipramine on the microstructure of licking for sucrose.

We previously reported that treatment with the prototypical antidepressant imipramine induced a dose-dependent reduction of the ingestion of a 10% sucrose solution, due to reduction of the licking burst number, thus suggesting reduced motivation and/or increased satiation.Importantly, the experimental sessions were performed in an alternate order,

read more